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Target
Oxysterols receptor LXR-beta
Ligand
BDBM93816
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR)
EC50
67539±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR) PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM93816
Synonyms:
2-[2-(2-bromanyl-4-chloranyl-phenoxy)ethylsulfanyl]pyrimidine | 2-[2-(2-bromo-4-chloro-phenoxy)ethylthio]pyrimidine | 2-[2-(2-bromo-4-chlorophenoxy)ethylsulfanyl]pyrimidine | 2-[2-(2-bromo-4-chlorophenoxy)ethylthio]pyrimidine | 2-{[2-(2-bromo-4-chlorophenoxy)ethyl]thio}pyrimidine | MLS000675409 | SMR000293424 | cid_2199876
Type:
Small organic molecule
Emp. Form.:
C12H10BrClN2OS
Mol. Mass.:
345.643
SMILES:
Clc1ccc(OCCSc2ncccn2)c(Br)c1
Structure:
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