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Target
Oxysterols receptor LXR-beta
Ligand
BDBM45062
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based screening assay to identify agonists of the Liver-X-Receptor (LXR).
IC50
67499±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based screening assay to identify agonists of the Liver-X-Receptor (LXR). PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM45062
Synonyms:
(6E)-3-methyl-6-(3-phenyl-3-isoxazolin-5-ylidene)cyclohexa-2,4-dien-1-one | (6Z)-3-methyl-6-(3-phenyl-2H-1,2-oxazol-5-ylidene)cyclohexa-2,4-dien-1-one | (6Z)-3-methyl-6-(3-phenyl-2H-isoxazol-5-ylidene)-1-cyclohexa-2,4-dienone | (6Z)-3-methyl-6-(3-phenyl-3-isoxazolin-5-ylidene)cyclohexa-2,4-dien-1-one | 5-methyl-2-(3-phenyl-5-isoxazolyl)phenol | MLS000583415 | SMR000193314 | cid_5414842
Type:
Small organic molecule
Emp. Form.:
C16H13NO2
Mol. Mass.:
251.2799
SMILES:
Cc1ccc(-c2cc(no2)-c2ccccc2)c(O)c1
Structure:
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