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Target
Oxysterols receptor LXR-beta
Ligand
BDBM42059
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based screening assay to identify agonists of the Liver-X-Receptor (LXR).
IC50
67504±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based screening assay to identify agonists of the Liver-X-Receptor (LXR). PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM42059
Synonyms:
MLS000391275 | N-[(Z)-(3-amino-1-isoindolylidene)amino]-4-(4-fluorophenyl)-2-thiazolamine | N-[(Z)-(3-aminoisoindol-1-ylidene)amino]-4-(4-fluorophenyl)-1,3-thiazol-2-amine | N-[(Z)-(3-azanylisoindol-1-ylidene)amino]-4-(4-fluorophenyl)-1,3-thiazol-2-amine | SMR000260312 | [(Z)-(3-aminoisoindol-1-ylidene)amino]-[4-(4-fluorophenyl)thiazol-2-yl]amine | cid_6261459
Type:
Small organic molecule
Emp. Form.:
C17H12FN5S
Mol. Mass.:
337.374
SMILES:
NC1=NC(=NNc2nc(cs2)-c2ccc(F)cc2)c2ccccc12 |w:4.4,t:1|
Structure:
Search PDB for entries with ligand similarity: