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Target
PC4 and SFRS1-interacting protein
Ligand
BDBM80810
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration
IC50
428.67±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration PubChem Bioassay (2014)[AID] 
Target
Name:
PC4 and SFRS1-interacting protein
Synonyms:
DFS70 | LEDGF | LEDGF/p75 | PSIP1 | PSIP1_HUMAN | PSIP2 | lens epithelium-derived growth factor p75
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60120.68
Organism:
Homo sapiens (Human)
Description:
gi_6708281
Residue:
530
Sequence:
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
  
Inhibitor
Name:
BDBM80810
Synonyms:
7-amino-6-chloro-5,8-diketo-naphthalene-2-sulfonamide | 7-amino-6-chloro-5,8-dioxo-2-naphthalenesulfonamide | 7-amino-6-chloro-5,8-dioxonaphthalene-2-sulfonamide | 7-azanyl-6-chloranyl-5,8-bis(oxidanylidene)naphthalene-2-sulfonamide | MLS002667101 | SMR001556873 | cid_240739
Type:
Small organic molecule
Emp. Form.:
C10H7ClN2O4S
Mol. Mass.:
286.692
SMILES:
NC1=C(Cl)C(=O)c2ccc(cc2C1=O)S(N)(=O)=O |c:1|
Structure:
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