Reaction Details Report a problem with these data
Target
Adenosine receptor A3 [I248L]
Ligand
BDBM175384
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
4.89e+3±n/a nM
Citation
 Yadav, R; Bansal, R; Rohilla, S; Kachler, S; Klotz, KN Synthesis and pharmacological characterization of novel xanthine carboxylate amides as A2A adenosine receptor ligands exhibiting bronchospasmolytic activity. Bioorg Chem 65:26-37 (2016) [PubMed]  Article 
Target
Name:
Adenosine receptor A3 [I248L]
Synonyms:
AA3R_HUMAN | ADORA3 | Adenosine receptor A3 | Adenosine receptor A3 (A3)
Type:
Protein
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8[I248L]
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSLINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM175384
Synonyms:
1,3-Dimethyl-8-[3-{2-(imidazol-1-yl)-2-oxoethoxy}-phenyl]xanthine (14h, RB-445)
Type:
Small organic molecule
Emp. Form.:
C18H16N6O4
Mol. Mass.:
380.3574
SMILES:
Cn1c2nc([nH]c2c(=O)n(C)c1=O)-c1cccc(OCC(=O)n2ccnc2)c1
Structure:
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