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Target
Monoacylglycerol lipase ABHD6
Ligand
BDBM444471
Substrate
n/a
Meas. Tech.
Fluorescent Assay
IC50
55±n/a nM
Citation
 Makriyannis, A; Malamas, M; Lamani, M; Farah, SI ABHD6 and dual ABHD6/MGL inhibitors and their uses US Patent  US10662159 Publication Date 5/26/2020 
Target
Name:
Monoacylglycerol lipase ABHD6
Synonyms:
2-arachidonoylglycerol hydrolase | ABHD6 | ABHD6_HUMAN | Abhydrolase domain-containing protein 6 | Monoacylglycerol lipase ABHD6
Type:
PROTEIN
Mol. Mass.:
38341.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105457
Residue:
337
Sequence:
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYSTDNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNNFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVELLENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD
  
Inhibitor
Name:
BDBM444471
Synonyms:
US10662159, Example 61
Type:
Small organic molecule
Emp. Form.:
C16H15F7N2O3
Mol. Mass.:
416.2907
SMILES:
Fc1cncc(OC2CCC3(CN(C3)C(=O)OC(C(F)(F)F)C(F)(F)F)C2)c1
Structure:
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