Reaction Details Report a problem with these data
Target
Guanylate cyclase soluble subunit alpha-1
Ligand
BDBM463186
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.479±n/a nM
Citation
Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators US Patent US10780092 Publication Date 9/22/2020
More Info.:
Target
Name:
Guanylate cyclase soluble subunit alpha-1
Synonyms:
GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC)
Type:
Enzyme
Mol. Mass.:
77457.21
Organism:
Homo sapiens (Human)
Description:
Q02108
Residue:
690
Sequence:
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
Inhibitor
Name:
BDBM463186
Synonyms:
4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-{8-[(3,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one | US10780092, Example 40-B
Type:
Small organic molecule
Emp. Form.:
C25H17ClF2N8O2
Mol. Mass.:
534.905
SMILES:
CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1cc(O)c(Cl)cn1