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Target
Rho-associated protein kinase 2
Ligand
BDBM464264
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
<3±n/a nM
Citation
 Bhide, RS; Bodas, MS; Shirude, PS; Patil, S; Maishal, TK; Thiyagarajan, K; Chinnakotti, K; Glunz, PW Spiro-fused cyclic ureas as inhibitors of rock US Patent  US10787450 Publication Date 9/29/2020 
Target
Name:
Rho-associated protein kinase 2
Synonyms:
KIAA0619 | ROCK-II | ROCK2 | ROCK2_HUMAN | Rho kinase 2 (ROCKII) | Rho-associated protein kinase 2 (ROCK-2) | Rho-associated protein kinase 2 (ROCK2) | Rho-associated protein kinase 2 (ROCKII) | Rho-associated protein kinase 2/Transforming protein RhoA | Rho-associated, coiled-coil-containing protein kinase 2 | Rho-associated, coiled-coil-containing protein kinase II | Serine/threonine-protein kinase RIO2 | p164 ROCK-2
Type:
Protein
Mol. Mass.:
160885.43
Organism:
Homo sapiens (Human)
Description:
O75116
Residue:
1388
Sequence:
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS
  
Inhibitor
Name:
BDBM464264
Synonyms:
3-(4-(1H-pyrazol-4- yl)phenyl)-8-(2- hydroxyethyl)-1-(3- methoxybenzyl)-2- oxo-1,3,8- triazaspiro[4.5]decane 8-oxide | US10787450, Example 145
Type:
Small organic molecule
Emp. Form.:
C26H31N5O4
Mol. Mass.:
477.5554
SMILES:
COc1cccc(CN2C(=O)N(CC22CC[N+]([O-])(CCO)CC2)c2ccc(cc2)-c2cn[nH]c2)c1 |(8.41,4.48,;8.79,2.99,;7.69,1.91,;8,.38,;6.91,-.7,;5.43,-.31,;5.03,1.18,;3.54,1.58,;2.21,.81,;.74,1.29,;-.03,2.62,;-.16,.04,;.74,-1.21,;2.21,-.73,;1.81,-2.22,;2.9,-3.31,;4.38,-2.91,;4.38,-4.45,;5.72,-3.68,;7.05,-2.91,;8.39,-3.68,;4.78,-1.42,;3.69,-.33,;-1.7,.04,;-2.47,-1.29,;-4.01,-1.29,;-4.78,.04,;-4.01,1.37,;-2.47,1.37,;-6.32,.04,;-7.23,-1.21,;-8.69,-.73,;-8.69,.81,;-7.23,1.29,;6.12,2.27,)|
Structure:
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