Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464457
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
1195±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793528 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464457
Synonyms:
US10793528, Example SC_5027
Type:
Small organic molecule
Emp. Form.:
C25H38N4O4
Mol. Mass.:
458.5936
SMILES:
CN[C@]1(CC[C@]2(CN(CCC(=O)NCCO)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:5.18,2.1,(5.79,3.59,;6.56,2.26,;5.79,.93,;5.02,-.41,;3.48,-.41,;2.71,.93,;1.8,2.17,;.34,1.7,;-.91,2.6,;-2.32,1.98,;-3.56,2.88,;-3.4,4.41,;-4.97,2.25,;-6.21,3.16,;-7.62,2.53,;-8.87,3.44,;.34,.16,;-.91,-.75,;1.8,-.32,;2.28,-1.78,;1.19,-2.87,;2.61,-3.46,;-.35,-2.87,;-.35,-4.41,;1.19,-4.41,;3.48,2.26,;5.02,2.26,;6.56,-.41,;5.79,-1.74,;6.56,-3.07,;8.1,-3.07,;8.87,-1.74,;8.1,-.41,)|
Structure:
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