Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464468
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
175±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793528 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464468
Synonyms:
US10793528, Example SC_5038
Type:
Small organic molecule
Emp. Form.:
C27H43N5O4
Mol. Mass.:
501.6614
SMILES:
COCCCN1C(=O)N(CCC(=O)NC(C)(C)C(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1 |r,wU:24.28,21.21,(.44,-5.72,;.44,-4.18,;1.52,-3.09,;1.13,-1.6,;2.21,-.51,;1.82,.98,;.35,1.45,;-.89,.55,;.35,2.99,;-.89,3.9,;-2.3,3.27,;-3.55,4.18,;-3.55,5.72,;-4.88,3.41,;-6.21,4.18,;-5.13,5.27,;-7.55,4.95,;-7.55,3.41,;-8.88,4.18,;-7.55,1.87,;1.82,3.47,;2.72,2.22,;3.49,.89,;5.03,.89,;5.8,2.22,;5.03,3.56,;3.49,3.56,;6.57,3.56,;8.11,3.56,;5.8,4.89,;6.57,.89,;5.8,-.45,;6.57,-1.78,;8.11,-1.78,;8.88,-.45,;8.11,.89,)|
Structure:
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