Reaction Details Report a problem with these data
Target
Prepronociceptin
Ligand
BDBM464476
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793528 Publication Date 10/6/2020 
Target
Name:
Prepronociceptin
Synonyms:
OFQ | PNOC | PNOC_HUMAN
Type:
Protein
Mol. Mass.:
20301.31
Organism:
Human
Description:
Q13519
Residue:
176
Sequence:
MKVLLCDLLLLSLFSSVFSSCQRDCLTCQEKLHPALDSFDLEVCILECEEKVFPSPLWTPCTKVMARSSWQLSPAAPEHVAAALYQPRASEMQHLRRMPRVRSLFQEQEEPEPGMEEAGEMEQKQLQKRFGGFTGARKSARKLANQKRFSEFMRQYLVLSMQSSQRRRTLHQNGNV
  
Inhibitor
Name:
BDBM464476
Synonyms:
US10793528, Example SC_5046
Type:
Small organic molecule
Emp. Form.:
C26H40N4O2
Mol. Mass.:
440.6214
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.18,3.2,(5.9,3.28,;4.37,3.12,;3.47,4.36,;3.75,1.71,;3.12,.3,;1.59,.14,;.68,1.39,;-.35,2.53,;-1.75,1.9,;-3.09,2.67,;-4.42,1.9,;-4.42,.36,;-4.42,3.44,;-5.75,2.67,;-7.09,1.9,;-5.75,4.21,;-1.59,.37,;-2.74,-.66,;-.09,.05,;.54,-1.35,;-.37,-2.6,;-1.89,-2.84,;-1.65,-4.36,;-.12,-4.12,;1.31,2.79,;2.84,2.95,;4.65,.46,;4.03,-.94,;4.93,-2.19,;6.46,-2.03,;7.09,-.62,;6.18,.62,)|
Structure:
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