Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464590
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
87.0±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464590
Synonyms:
CIS-1-(Cyclobutyl-methyl)-8-methylamino-3-(2-methylsulfonyl-ethyl)-8-phenyl- 1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4010
Type:
Small organic molecule
Emp. Form.:
C23H35N3O3S
Mol. Mass.:
433.607
SMILES:
CN[C@]1(CC[C@]2(CN(CCS(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:5.16,2.1,(7.24,-2.67,;8.01,-4,;7.24,-5.34,;6.47,-6.67,;4.93,-6.67,;4.16,-5.34,;3.25,-4.09,;1.79,-4.57,;.7,-3.48,;-.79,-3.88,;-1.88,-2.79,;-3.37,-3.19,;-2.97,-1.7,;-.79,-1.7,;1.79,-6.11,;.54,-7.01,;3.25,-6.58,;3.73,-8.05,;2.7,-9.19,;1.16,-9.19,;1.16,-10.73,;2.7,-10.73,;4.93,-4,;6.47,-4,;8.01,-6.67,;7.24,-8.01,;8.01,-9.34,;9.55,-9.34,;10.32,-8.01,;9.55,-6.67,)|
Structure:
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