Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464592
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
99.7±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464592
Synonyms:
CIS-4-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-butyronitrile | US10793556, Example SC_4012
Type:
Small organic molecule
Emp. Form.:
C25H36N4O
Mol. Mass.:
408.5795
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CCCC#N)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.16,3.2,(6.97,-2.18,;7.74,-3.52,;9.28,-3.52,;6.97,-4.85,;6.2,-6.19,;4.66,-6.19,;3.89,-4.85,;2.98,-3.61,;1.52,-4.08,;.43,-2.99,;-1.06,-3.39,;-2.15,-2.3,;-3.63,-2.7,;-5.12,-3.1,;1.52,-5.62,;.27,-6.53,;2.98,-6.1,;3.46,-7.56,;2.43,-8.71,;.89,-8.71,;.89,-10.25,;2.43,-10.25,;4.66,-3.52,;6.2,-3.52,;7.74,-6.19,;6.97,-7.52,;7.74,-8.85,;9.28,-8.85,;10.05,-7.52,;9.28,-6.19,)|
Structure:
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