Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464643
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
460±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464643
Synonyms:
CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-methyl-2-(2-oxo-pyrrolidin-1- yl)-propyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4072 | US10793556, Example SC_4073 | US10793556, Example SC_4074 | US10793556, Example SC_4075 | US10793556, Example SC_4076
Type:
Small organic molecule
Emp. Form.:
C28H43N3O4S
Mol. Mass.:
517.724
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(5.31,-14.15,;3.77,-14.15,;3,-12.81,;3,-15.48,;2.23,-16.81,;.69,-16.81,;-.08,-15.48,;-.98,-14.23,;-2.45,-14.71,;-3.78,-13.94,;-5.12,-14.71,;-6.45,-13.94,;-7.78,-14.71,;-5.12,-13.17,;-5.12,-11.63,;-6.45,-10.86,;-7.22,-9.53,;-5.68,-9.53,;-7.78,-11.63,;-7.78,-13.17,;-2.45,-16.25,;-3.69,-17.16,;-.98,-16.73,;-.51,-18.19,;-1.54,-19.33,;-3.08,-19.33,;-3.08,-20.87,;-1.54,-20.87,;.69,-14.15,;2.23,-14.15,;3.77,-16.81,;3,-18.15,;3.77,-19.48,;5.31,-19.48,;6.08,-18.15,;5.31,-16.81,)|
Structure:
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