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Target
Short transient receptor potential channel 6
Ligand
BDBM466585
Substrate
n/a
Meas. Tech.
High Throughput Screening Assay
IC50
<27.0±n/a nM
Citation
 Bouyssou, T; Gottschling, D; Heine, N; Keenan, LL; Lowe, MD; Razavi, H; Sarko, CR; Surprenant, S; Takahashi, H; Turner, MR; Wu, X Inhibitors of TRPC6 US Patent  US10800757 Publication Date 10/13/2020 
Target
Name:
Short transient receptor potential channel 6
Synonyms:
TRP-6 | TRP6 | TRPC6 | TRPC6_HUMAN | Transient receptor protein 6
Type:
PROTEIN
Mol. Mass.:
106326.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107640
Residue:
931
Sequence:
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR
  
Inhibitor
Name:
BDBM466585
Synonyms:
US10800757, Compound 1 | US10889568, Compound 1 | [4-(6-Amino-4-methoxy-pyridin-3-yl)- piperazin-1-yl]-[5-(4-fluoro- phenoxy)-4-methoxy-pyridin-2-yl]- methanone
Type:
Small organic molecule
Emp. Form.:
C23H24FN5O4
Mol. Mass.:
453.4662
SMILES:
COc1cc(ncc1Oc1ccc(F)cc1)C(=O)N1CCN(CC1)c1cnc(N)cc1OC
Structure:
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