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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM388935
Substrate
n/a
Meas. Tech.
LSD1 histone demethylase biochemical assay
IC50
<50±n/a nM
Citation
 He, C; Li, Z; Wu, L; Yao, W; Zhang, F Heterocyclic compounds as LSD1 inhibitors US Patent  US10800779 Publication Date 10/13/2020 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM388935
Synonyms:
4-[5-[4-(dimethylamino)piperidin-1-yl]-8-(5-fluoro-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)imidazo[1,2-c]pyrimidin-7-yl]benzonitrile | US10800779, Example 54 | US11401272, Example 54 | US9944647, Example 54
Type:
Small organic molecule
Emp. Form.:
C28H26FN7O2
Mol. Mass.:
511.5501
SMILES:
CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cc3oc(=O)n(C)c3cc2F)c2nccn12 |(8.62,2.83,;7.29,3.6,;7.29,5.14,;5.96,2.83,;5.96,1.29,;4.62,.52,;3.29,1.29,;3.29,2.83,;4.62,3.6,;1.95,.52,;.62,1.29,;-.71,.52,;-2.05,1.29,;-2.05,2.83,;-3.38,3.6,;-4.76,2.86,;-4.71,1.29,;-3.38,.52,;-6.1,3.63,;-7.43,4.4,;-.71,-1.02,;-2.05,-1.79,;-3.38,-1.02,;-4.71,-1.79,;-6.18,-1.31,;-7.08,-2.56,;-8.62,-2.56,;-6.18,-3.81,;-6.95,-5.14,;-4.71,-3.33,;-3.38,-4.1,;-2.05,-3.33,;-.71,-4.1,;.62,-1.79,;.94,-3.3,;2.47,-3.46,;3.1,-2.05,;1.95,-1.02,)|
Structure:
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