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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM389018
Substrate
n/a
Meas. Tech.
LSD1 histone demethylase biochemical assay
IC50
<50±n/a nM
Citation
 He, C; Li, Z; Wu, L; Yao, W; Zhang, F Heterocyclic compounds as LSD1 inhibitors US Patent  US10800779 Publication Date 10/13/2020 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM389018
Synonyms:
4-[5-[4-(dimethylamino)piperidin-1- yl]-8-(4-fluoro-1,3-dimethyl-2-oxo- 2,3-dihydro-1H-benzimidazol-5- yl)imidazo[1,2-c]pyrimidin-7- yl]benzonitrile | US10800779, Example 127 | US11401272, Example 127 | US9944647, Example 127
Type:
Small organic molecule
Emp. Form.:
C29H29FN8O
Mol. Mass.:
524.592
SMILES:
CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3n(C)c(=O)n(C)c3c2F)c2nccn12 |(8.62,2.91,;7.29,3.68,;7.29,5.22,;5.96,2.91,;5.96,1.37,;4.62,.6,;3.29,1.37,;3.29,2.91,;4.62,3.68,;1.95,.6,;.62,1.37,;-.71,.6,;-2.05,1.37,;-2.05,2.91,;-3.38,3.68,;-4.76,2.93,;-4.71,1.37,;-3.38,.6,;-6.1,3.7,;-7.43,4.47,;-.71,-.94,;-2.05,-1.71,;-2.05,-3.25,;-3.38,-4.02,;-4.71,-3.25,;-6.18,-3.73,;-6.58,-5.22,;-7.08,-2.48,;-8.62,-2.48,;-6.18,-1.24,;-6.58,.25,;-4.71,-1.71,;-3.38,-.94,;-4.71,-.17,;.62,-1.71,;1.18,-3.31,;2.72,-3.31,;3.2,-1.85,;1.95,-.94,)|
Structure:
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