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Target
Nociceptin receptor
Ligand
BDBM469817
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.60±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469817
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-(5-methyl-pyridin-2-yl)-acetamide | US10807989, Example SC_1045
Type:
Small organic molecule
Emp. Form.:
C29H39N5O2
Mol. Mass.:
489.6523
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccc(C)cn3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(18.81,8.11,;17.32,8.5,;16.92,9.99,;16.23,7.41,;15.14,6.33,;13.66,6.72,;13.26,8.21,;12.35,9.46,;10.89,8.98,;9.8,10.07,;8.31,9.67,;7.91,8.18,;7.22,10.76,;5.74,10.36,;5.34,8.88,;3.85,8.48,;2.76,9.57,;1.27,9.17,;3.16,11.05,;4.65,11.45,;10.89,7.44,;9.55,6.67,;12.35,6.97,;12.75,5.48,;11.66,4.39,;10.12,4.39,;10.12,2.85,;11.66,2.85,;14.35,9.3,;15.83,8.9,;17.32,6.33,;16.92,4.84,;18.01,3.75,;19.5,4.15,;19.9,5.64,;18.81,6.72,)|
Structure:
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