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Target
Nociceptin receptor
Ligand
BDBM469847
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.50±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469847
Synonyms:
CIS-N-(2-Cyano-pyrimidin-5-yl)-2-[1-(cyclobutyl-methyl)-8-dimethylamino-2-oxo- 8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-acetamide | US10807989, Example SC_1075
Type:
Small organic molecule
Emp. Form.:
C28H35N7O2
Mol. Mass.:
501.6232
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cnc(nc3)C#N)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.24,3.2,(-2.1,-22.25,;-3.59,-21.85,;-3.99,-20.36,;-4.68,-22.94,;-5.45,-24.28,;-6.99,-24.28,;-7.76,-22.94,;-8.67,-21.7,;-10.13,-22.17,;-11.22,-21.08,;-12.71,-21.48,;-13.1,-22.97,;-13.8,-20.39,;-15.28,-20.79,;-16.37,-19.7,;-17.86,-20.1,;-18.26,-21.59,;-17.17,-22.68,;-15.68,-22.28,;-19.75,-21.99,;-21.23,-22.38,;-10.13,-23.71,;-11.46,-24.48,;-8.67,-24.19,;-8.27,-25.67,;-9.36,-26.76,;-10.9,-26.76,;-10.9,-28.3,;-9.36,-28.3,;-6.99,-21.61,;-5.45,-21.61,;-3.91,-24.28,;-4.68,-25.61,;-3.91,-26.94,;-2.37,-26.94,;-1.6,-25.61,;-2.37,-24.28,)|
Structure:
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