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Target
Nociceptin receptor
Ligand
BDBM469861
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.40±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469861
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-[(2-hydroxyphenyl)-methyl]-acetamide | US10807989, Example SC_1089
Type:
Small organic molecule
Emp. Form.:
C30H40N4O3
Mol. Mass.:
504.6636
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCc3ccccc3O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.24,3.2,(-6.65,17.89,;-5.56,16.8,;-4.07,17.2,;-5.96,15.31,;-5.96,13.77,;-7.29,13,;-8.62,13.77,;-9.91,14.61,;-11.11,13.64,;-12.6,14.04,;-13.69,12.95,;-13.29,11.47,;-15.18,13.35,;-16.26,12.26,;-17.75,12.66,;-18.84,11.57,;-20.33,11.97,;-20.73,13.46,;-19.64,14.55,;-18.15,14.15,;-17.06,15.24,;-10.56,12.21,;-11.33,10.87,;-9.02,12.29,;-7.93,11.2,;-8.33,9.71,;-9.67,8.94,;-8.9,7.61,;-7.56,8.38,;-8.62,15.31,;-7.29,16.08,;-4.47,14.92,;-4.07,13.43,;-2.58,13.03,;-1.49,14.12,;-1.89,15.61,;-3.38,16,)|
Structure:
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