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Target
Mu-type opioid receptor
Ligand
BDBM472059
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
3.40±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM472059
Synonyms:
CIS-1-[[8-Dimethylamino-3-[(4-methoxyphenyl)-methyl]-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-l-yl]-methyl-cyclobutane-1-carbonitrile | US10829480, Example SC_2074
Type:
Small organic molecule
Emp. Form.:
C30H38N4O2
Mol. Mass.:
486.6483
SMILES:
COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3(CCC3)C#N)C2=O)cc1 |r,wU:9.25,12.15,(2.75,-13.64,;4.09,-14.41,;5.42,-13.64,;5.42,-12.1,;6.76,-11.33,;8.09,-12.1,;9.42,-11.33,;10.76,-12.1,;12.22,-11.63,;13.13,-12.87,;13.9,-14.21,;15.44,-14.21,;16.21,-12.87,;15.44,-11.54,;13.9,-11.54,;16.98,-11.54,;16.21,-10.21,;18.52,-11.54,;16.98,-14.21,;16.21,-15.54,;16.98,-16.87,;18.52,-16.87,;19.29,-15.54,;18.52,-14.21,;12.22,-14.12,;12.62,-15.61,;11.53,-16.7,;9.99,-16.7,;9.99,-18.24,;11.53,-18.24,;12.86,-17.47,;14.2,-18.24,;10.76,-13.64,;9.42,-14.41,;8.09,-13.64,;6.76,-14.41,)|
Structure:
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