Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM472437
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
>5000±n/a nM
Citation
 Wang, J; Zhang, Y; Zhu, W; Chen, S Thiophene, manufacturing method thereof, and pharmaceutical application of same US Patent  US10829483 Publication Date 11/10/2020 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM472437
Synonyms:
US10829483, Compound WX038
Type:
Small organic molecule
Emp. Form.:
C17H13BrFN3O2S2
Mol. Mass.:
454.336
SMILES:
OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCc12)-c1ccc(F)cc1 |(4.83,5.72,;3.74,4.63,;4.14,3.15,;2.25,5.03,;1.16,3.94,;-.32,4.34,;-.8,5.81,;-2.34,5.81,;-2.81,4.34,;-4.15,3.57,;-1.57,3.44,;-1.57,1.9,;-.32,.99,;-.8,-.47,;-2.34,-.47,;-3.58,-1.38,;-4.83,-.47,;-4.35,.99,;-2.81,.99,;-.03,-1.81,;-.8,-3.14,;-.03,-4.47,;1.51,-4.47,;2.28,-5.81,;2.28,-3.14,;1.51,-1.81,)|
Structure:
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