Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM472438
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
>5000±n/a nM
Citation
 Wang, J; Zhang, Y; Zhu, W; Chen, S Thiophene, manufacturing method thereof, and pharmaceutical application of same US Patent  US10829483 Publication Date 11/10/2020 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM472438
Synonyms:
US10829483, Compound WX039
Type:
Small organic molecule
Emp. Form.:
C17H13BrFN3O2S2
Mol. Mass.:
454.336
SMILES:
OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCc12)-c1cccc(F)c1 |(4.83,5.06,;3.74,3.97,;4.14,2.48,;2.25,4.37,;1.16,3.28,;-.32,3.68,;-.8,5.14,;-2.34,5.14,;-2.81,3.68,;-4.15,2.91,;-1.57,2.77,;-1.57,1.23,;-.32,.33,;-.8,-1.14,;-2.34,-1.14,;-3.58,-2.04,;-4.83,-1.14,;-4.35,.33,;-2.81,.33,;-.03,-2.47,;-.8,-3.81,;-.03,-5.14,;1.51,-5.14,;2.28,-3.81,;3.82,-3.81,;1.51,-2.47,)|
Structure:
Search PDB for entries with ligand similarity: