Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM472449
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
>5000±n/a nM
Citation
 Wang, J; Zhang, Y; Zhu, W; Chen, S Thiophene, manufacturing method thereof, and pharmaceutical application of same US Patent  US10829483 Publication Date 11/10/2020 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM472449
Synonyms:
US10829483, Compound WX046
Type:
Small organic molecule
Emp. Form.:
C21H22BrN3O2S2
Mol. Mass.:
492.452
SMILES:
CC(C)(C)c1ccc(cc1)-c1sc(c2CCCc12)-n1c(Br)nnc1SCC(O)=O |(1.51,-6.47,;2.28,-5.14,;3.82,-5.14,;3.05,-6.47,;1.51,-3.81,;-.03,-3.81,;-.8,-2.47,;-.03,-1.14,;1.51,-1.14,;2.28,-2.47,;-.8,.19,;-.32,1.66,;-1.57,2.56,;-2.81,1.66,;-4.35,1.66,;-4.83,.19,;-3.58,-.71,;-2.34,.19,;-1.57,4.1,;-2.81,5.01,;-4.15,4.24,;-2.34,6.47,;-.8,6.47,;-.32,5.01,;1.16,4.61,;2.25,5.7,;3.74,5.3,;4.83,6.39,;4.14,3.81,)|
Structure:
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