Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] B
Ligand
BDBM472860
Substrate
n/a
Meas. Tech.
MAOA and MAOB In Vitro Activity Experiments
IC50
12780±1350 nM
Citation
 Liu, H; Li, J; Wang, J; Su, M; Wang, S; Zhou, Y; Zhu, W; Xu, W; Li, C; Jiang, H; Chen, K Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and uses thereof US Patent  US10836743 Publication Date 11/17/2020 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM472860
Synonyms:
Methyl 4-((4-fluoro-4-(((trans-2-phenylcyclo- propyl)amino)methyl)piperidin-1-yl) methyl)benzoate | US10836743, Compound A3
Type:
Small organic molecule
Emp. Form.:
C24H29FN2O2
Mol. Mass.:
396.4977
SMILES:
COC(=O)c1ccc(CN2CCC(F)(CNC3CC3c3ccccc3)CC2)cc1
Structure:
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