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Target
Mitogen-activated protein kinase 1
Ligand
BDBM365054
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
1.15±n/a nM
Citation
 Kolesnikov, A; Do, S Serine/threonine kinase inhibitors US Patent  US10842799 Publication Date 11/24/2020 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM365054
Synonyms:
(R)-9-isobutyl-6,8-dimethyl- 4-(2-((1-methyl-1H-pyrazol- 5-yl)amino)pyrimidin-4-yl)- 8,9-dihydro-1,2,2a1,6,8- pentaazabenzo[cd]azulen- 7(6H)-one | US10278975, Compound I-19 | US10517878, Compound I-19 | US10842799, I-19 | US11376260, Example I-19 | US9867833, Compound I-19
Type:
Small organic molecule
Emp. Form.:
C22H26N10O
Mol. Mass.:
446.5082
SMILES:
CC(C)C[C@H]1N(C)C(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1 |r|
Structure:
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