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Target
Mitogen-activated protein kinase 1
Ligand
BDBM365064
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
4.28±n/a nM
Citation
 Kolesnikov, A; Do, S Serine/threonine kinase inhibitors US Patent  US10842799 Publication Date 11/24/2020 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM365064
Synonyms:
(R)-9-isobutyl-6-methyl-4- (2-((1-methyl-1H-pyrazol-5- yl)amino)pyridin-4-yl)-8,9- dihydro-1,2,2a1,6,8- pentaazabenzo[cd]azulen- 7(6H)-one | US10278975, Compound I-25 | US10517878, Compound I-25 | US10842799, I-25 | US11376260, Example I-25 | US9867833, Compound I-25
Type:
Small organic molecule
Emp. Form.:
C22H25N9O
Mol. Mass.:
431.4936
SMILES:
CC(C)C[C@H]1NC(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)c1 |r|
Structure:
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