Reaction Details Report a problem with these data
Target
WD repeat-containing protein 5
Ligand
BDBM473194
Substrate
n/a
Meas. Tech.
TR-FRET Binding Assay
Ki
<0.100±n/a nM
Citation
 Alvarado, JR; Stauffer, SR; Gogliotti, RD; Han, C; Meyers, KM; Tian, J; Macdonald, JD; Fesik, SW; Lee, T WDR5 inhibitors and modulators US Patent  US10844044 Publication Date 11/24/2020 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM473194
Synonyms:
US10844044, Example 2
Type:
Small organic molecule
Emp. Form.:
C29H32N6O2
Mol. Mass.:
496.6034
SMILES:
COc1ncc(C)cc1-c1cc(Cn2ccn(C)c2=N)cc(c1)C(=O)NC(C1CC1)c1cc(C)ccn1
Structure:
Search PDB for entries with ligand similarity: