Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM473794
Substrate
n/a
Meas. Tech.
HDAC Enzyme Assays
IC50
105±n/a nM
Citation
 Golonzhka, O; Jarpe, MB HDAC inhibitors for the treatment of diabetic peripheral neuropathy US Patent  US10858323 Publication Date 12/8/2020 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM473794
Synonyms:
N-hydroxy-2-((2-methoxy-5-(trifluoromethyl)benzyl)amino)pyrimidine-5-carboxamide | US10858323, Compound 3
Type:
Small organic molecule
Emp. Form.:
C14H13F3N4O3
Mol. Mass.:
342.2732
SMILES:
COc1ccc(cc1CNc1ncc(cn1)C(=O)NO)C(F)(F)F
Structure:
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