Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM474415
Substrate
n/a
Meas. Tech.
MAGL Enzymatic Assay (0 minute)
IC50
1950±n/a nM
Citation
 Brodney, MA; Butler, CR; McAllister, LA; Helal, CJ; O''Neil, SV; Verhoest, PR Heterocyclic spiro compounds as MAGL inhibitors US Patent  US10858373 Publication Date 12/8/2020 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM474415
Synonyms:
1-({[(3R)-3-(4-Fluoro-1H-pyrazol-1-yl)-1-oxa-8-azaspiro[4.5]dec-8-yl]carbonyl}oxy)pyrrolidine-2,5-dione | US10858373, Example 13
Type:
Small organic molecule
Emp. Form.:
C16H19FN4O5
Mol. Mass.:
366.3443
SMILES:
Fc1cnn(c1)[C@H]1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O |r|
Structure:
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