Reaction Details Report a problem with these data
Target
ADP-ribosylation factor 6
Ligand
BDBM474999
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
2.50±n/a nM
Citation
 Ostanin, K; Shenderovich, M; Bajji, A; Cioffi, CL; Moss, N; Vankayalapati, H; Li, D Arf6 inhibitors and methods of synthesis and use thereof US Patent  US10849901 Publication Date 12/1/2020 
Target
Name:
ADP-ribosylation factor 6
Synonyms:
ARF6 | ARF6_HUMAN
Type:
Protein
Mol. Mass.:
20087.47
Organism:
Human
Description:
P62330
Residue:
175
Sequence:
MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS
  
Inhibitor
Name:
BDBM474999
Synonyms:
US10849901, Compound 49
Type:
Small organic molecule
Emp. Form.:
C25H17Cl2N3O
Mol. Mass.:
446.328
SMILES:
Clc1ccc(cc1)-c1c(Cc2ccccc2)nn2c1[nH]c(-c1ccccc1)c(Cl)c2=O
Structure:
Search PDB for entries with ligand similarity: