Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-gamma
Ligand
BDBM475863
Substrate
n/a
Meas. Tech.
Fluorescence Resonance Energy Transfer (FRET) Assay
IC50
<500±n/a nM
Citation
 Wang, Y; Huang, Y; Yu, F; Tang, T Biaryl urea derivative or salt thereof and preparation process and use for the same US Patent  US10851050 Publication Date 12/1/2020 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM475863
Synonyms:
2-(4-((3-(2,6-dichloro-2′-(difluoromethoxy)-[1,1′-biphenyl]-4-yl)ureido)methyl)phenyl)acetic acid) | US10851050, Example I-20
Type:
Small organic molecule
Emp. Form.:
C23H18Cl2F2N2O4
Mol. Mass.:
495.303
SMILES:
OC(=O)Cc1ccc(CNC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)F)cc1 |(10.4,1.93,;8.86,1.93,;8.09,3.26,;8.09,.59,;6.55,.59,;5.78,-.74,;4.24,-.74,;3.46,.59,;1.93,.59,;1.15,-.74,;-.39,-.74,;-1.15,.59,;-1.15,-2.07,;-2.7,-2.07,;-3.46,-3.41,;-5,-3.41,;-5.78,-4.74,;-5.78,-2.07,;-5,-.74,;-5.78,.59,;-3.46,-.74,;-7.32,-2.07,;-8.09,-3.41,;-9.63,-3.41,;-10.4,-2.07,;-9.63,-.74,;-8.09,-.74,;-7.32,.59,;-8.09,1.93,;-9.63,1.93,;-7.32,3.26,;4.24,1.93,;5.78,1.93,)|
Structure:
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