Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 11 [E76K]
Ligand
BDBM384181
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
1894±n/a nM
Citation
 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA Heterocyclic inhibitors of PTPN11 US Patent  US10851110 Publication Date 12/1/2020 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11 [E76K]
Synonyms:
PTN11_HUMAN | PTP2C | PTPN11 | Protein-tyrosine phosphatase 1D | SHPTP2 | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)(E76K)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
68019.14
Organism:
Homo sapiens (Human)
Description:
Q06124[E76K]
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM384181
Synonyms:
4-Methyl-1-(3-(5-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-amine | US10280171, Example 101 | US10851110, Example 101 | US11466017, Example 101
Type:
Small organic molecule
Emp. Form.:
C15H17F3N8
Mol. Mass.:
366.3443
SMILES:
CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cn[nH]c1C(F)(F)F
Structure:
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