Reaction Details Report a problem with these data
Target
Capsid protein
Ligand
BDBM476239
Substrate
n/a
Meas. Tech.
HBV DNA Quantification Assay
EC50
27.1±n/a nM
Citation
 Du, J; Kaplan, JA; Kirschberg, TA; Kobayashi, T; Lazerwith, SE; Lee, RA; Medley, JW; Mitchell, ML; Morganelli, PA; Pyun, H; Shevick, SL; Squires, NH; Watkins, WJ Substituted pyrrolizine compounds and uses thereof US Patent  US10874640 Publication Date 12/29/2020 
Target
Name:
Capsid protein
Synonyms:
C | CAPSD_HBVCJ | Core antigen | Core protein | HBcAg | p21.5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21105.01
Organism:
Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C)
Description:
n/a
Residue:
183
Sequence:
MDIDPYKEFGASVELLSFLPSDFFPSIRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMNLATWVGSNLEDPASRELVVSYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
  
Inhibitor
Name:
BDBM476239
Synonyms:
US10874640, Compound 1
Type:
Small organic molecule
Emp. Form.:
C20H15ClF4N4O3
Mol. Mass.:
470.805
SMILES:
CC(NC(=O)C(=O)c1c(Cl)c(C(=O)Nc2ccc(F)c(c2)C#N)n2CCCc12)C(F)(F)F
Structure:
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