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Target
D(3) dopamine receptor
Ligand
BDBM476245
Substrate
n/a
Meas. Tech.
radioligand competition assay
Ki
10.4±1.6 nM
Citation
 Dutta, AK Neuroprotective agents for treatment of neurodegenerative diseases US Patent  US10874669 Publication Date 12/29/2020 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM476245
Synonyms:
6-((2-(4-(4-chloro-1H-indol-5-yl)piperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol | US10874669, Compound 12
Type:
Small organic molecule
Emp. Form.:
C27H35ClN4O
Mol. Mass.:
467.046
SMILES:
CCCN(CCN1CCN(CC1)c1ccc2[nH]ccc2c1Cl)C1CCc2c(O)cccc2C1
Structure:
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