Reaction Details Report a problem with these data
Target
Receptor activity-modifying protein 1
Ligand
BDBM391729
Substrate
n/a
Meas. Tech.
Radioligand binding assay
Ki
0.079±n/a nM
Citation
 Christopher, JA; Congreve, MS; Bucknell, SJ; Deflorian, F; Pickworth, M; Mason, JS CGRP receptor antagonists US Patent  US10888561 Publication Date 1/12/2021 
Target
Name:
Receptor activity-modifying protein 1
Synonyms:
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | RAMP1 | RAMP1_HUMAN
Type:
PROTEIN
Mol. Mass.:
16992.80
Organism:
Homo sapiens (Human)
Description:
EBI_100673
Residue:
148
Sequence:
MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV
  
Inhibitor
Name:
BDBM391729
Synonyms:
3,5-dibromo-Nalpha-[(2'-oxo- | US10300056, Example 14 | US10888561, Example 14
Type:
Small organic molecule
Emp. Form.:
C38H45Br2N9O6
Mol. Mass.:
883.629
SMILES:
Oc1c(Br)cc(C[C@@H](NC(=O)N2CCC3(CC2)OC(=O)Nc2ncccc32)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(CC2)c2ccncc2)cc1Br |r|
Structure:
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