Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM479514
Substrate
n/a
Meas. Tech.
Binding Affinity Assay
IC50
3.30±n/a nM
Citation
 Qi, C; Tsui, H; Zeng, Q; Yang, Z; Zhang, X Pyrazine compounds and uses thereof US Patent  US10898481 Publication Date 1/26/2021 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM479514
Synonyms:
3-amino-N-(2,6-difluorobenzyl)-6-(1- (2-hydroxyethyl)-6-oxo-1,6- dihydropyridin-3-yl)-5-(oxazol-2-yl) pyrazine-2-carboxamide | US10898481, Compound 41 | US11571420, Compound 41
Type:
Small organic molecule
Emp. Form.:
C22H18F2N6O4
Mol. Mass.:
468.4129
SMILES:
Nc1nc(-c2ncco2)c(nc1C(=O)NCc1c(F)cccc1F)-c1ccc(=O)n(CCO)c1
Structure:
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