Reaction Details Report a problem with these data
Target
Fatty acid 2-hydroxylase
Ligand
BDBM483665
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
550±n/a nM
Citation
 Grice, CA; Wiener, JJ; Weber, OD; Duncan, KK Pyrazole MAGL inhibitors US Patent  US10927105 Publication Date 2/23/2021 
Target
Name:
Fatty acid 2-hydroxylase
Synonyms:
FA2H | FA2H_HUMAN | FAAH | FAXDC1 | Fatty acid alpha-hydroxylase | Fatty acid hydroxylase domain-containing protein 1
Type:
Protein
Mol. Mass.:
42806.38
Organism:
Human
Description:
Q7L5A8
Residue:
372
Sequence:
MAPAPPPAASFSPSEVQRRLAAGACWVRRGARLYDLSSFVRHHPGGEQLLRARAGQDISADLDGPPHRHSANARRWLEQYYVGELRGEQQGSMENEPVALEETQKTDPAMEPRFKVVDWDKDLVDWRKPLLWQVGHLGEKYDEWVHQPVTRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVLYLSWSYYRTFAQGNVRLFTSFTTEYTVAVPKSMFPGLFMLGTFLWSLIEYLIHRFLFHMKPPSDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVIGVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHTLTPEKPHLKTQ
  
Inhibitor
Name:
BDBM483665
Synonyms:
1-(4-(3-((4- (trifluoromethyl)- pyridin-2- yl)oxy)benzyl)- piperazine-1- carbonyl)- 1H-pyrazole-3- carboxylic acid | US10927105, Ex 57 | US11655217, Example 57
Type:
Small organic molecule
Emp. Form.:
C22H20F3N5O4
Mol. Mass.:
475.4205
SMILES:
OC(=O)c1ccn(n1)C(=O)N1CCN(Cc2cccc(Oc3cc(ccn3)C(F)(F)F)c2)CC1
Structure:
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