Reaction Details Report a problem with these data
Target
Fatty acid 2-hydroxylase
Ligand
BDBM483693
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
<100±n/a nM
Citation
 Grice, CA; Wiener, JJ; Weber, OD; Duncan, KK Pyrazole MAGL inhibitors US Patent  US10927105 Publication Date 2/23/2021 
Target
Name:
Fatty acid 2-hydroxylase
Synonyms:
FA2H | FA2H_HUMAN | FAAH | FAXDC1 | Fatty acid alpha-hydroxylase | Fatty acid hydroxylase domain-containing protein 1
Type:
Protein
Mol. Mass.:
42806.38
Organism:
Human
Description:
Q7L5A8
Residue:
372
Sequence:
MAPAPPPAASFSPSEVQRRLAAGACWVRRGARLYDLSSFVRHHPGGEQLLRARAGQDISADLDGPPHRHSANARRWLEQYYVGELRGEQQGSMENEPVALEETQKTDPAMEPRFKVVDWDKDLVDWRKPLLWQVGHLGEKYDEWVHQPVTRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVLYLSWSYYRTFAQGNVRLFTSFTTEYTVAVPKSMFPGLFMLGTFLWSLIEYLIHRFLFHMKPPSDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVIGVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHTLTPEKPHLKTQ
  
Inhibitor
Name:
BDBM483693
Synonyms:
4-chloro-1-(1-((6- (trifluoromethyl)- benzo[b]thiophen-2- yl)methyl)-1,8- diazaspiro[4.5]- decane-8- carbonyl)-1H- pyrazole-3- carboxylic acid | US10927105, Ex 139 | US11655217, Example 139
Type:
Small organic molecule
Emp. Form.:
C23H22ClF3N4O3S
Mol. Mass.:
526.959
SMILES:
OC(=O)c1nn(cc1Cl)C(=O)N1CCC2(CCCN2Cc2cc3ccc(cc3s2)C(F)(F)F)CC1
Structure:
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