Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM483832
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
<100±n/a nM
Citation
 Grice, CA; Wiener, JJ; Weber, OD; Duncan, KK Pyrazole MAGL inhibitors US Patent  US10927105 Publication Date 2/23/2021 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM483832
Synonyms:
1-(4-(2-((2R,5R)- 2,5- dimethylpyrrolidin- 1-yl)-4- (trifluoromethyl)- benzyl)piperazine- 1-carbonyl)-1H- pyrazole-3- carboxylic acid | US10927105, Ex 359 | US11655217, Example 359
Type:
Small organic molecule
Emp. Form.:
C23H28F3N5O3
Mol. Mass.:
479.4953
SMILES:
C[C@@H]1CC[C@@H](C)N1c1cc(ccc1CN1CCN(CC1)C(=O)n1ccc(n1)C(O)=O)C(F)(F)F |r|
Structure:
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