Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM486432
Substrate
n/a
Meas. Tech.
DGAT2 Enzymatic Activity Assay
IC50
175±n/a nM
Citation
 Shen, D; Graham, TH; Jiang, J; Ding, F; Tudge, C Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US10947222 Publication Date 3/16/2021 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM486432
Synonyms:
US10947222, Example 60 | methyl 4-{6-[(1,1- dioxidotetrahydrothiophen-3- yl)carbamoyl]-1-(4-fluorophenyl)- 1H-indol-3-yl}thiophene-2- carboxylate (racemic)
Type:
Small organic molecule
Emp. Form.:
C25H21FN2O5S2
Mol. Mass.:
512.573
SMILES:
COC(=O)c1cc(cs1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Structure:
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