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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487562
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487562
Synonyms:
US10954193, Example 113
Type:
Small organic molecule
Emp. Form.:
C34H42Cl2N4O4
Mol. Mass.:
641.628
SMILES:
Cc1nn(CCN2CCOCC2)c(C)c1-c1c(Cl)ccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(CCC(O)=O)c12 |(-.2,-.33,;-1.54,-1.1,;-2.01,-2.57,;-3.55,-2.57,;-4.32,-3.9,;-5.86,-3.9,;-6.63,-5.23,;-8.17,-5.23,;-8.94,-6.57,;-8.17,-7.9,;-6.63,-7.9,;-5.86,-6.57,;-4.03,-1.1,;-5.36,-.33,;-2.78,-.2,;-2.78,1.34,;-4.12,2.11,;-5.45,1.34,;-4.12,3.65,;-2.78,4.42,;-1.45,3.65,;.02,4.13,;.42,5.62,;1.9,6.02,;2.3,7.5,;3.79,7.9,;4.88,6.81,;4.48,5.32,;5.57,4.24,;5.17,2.75,;7.06,4.63,;8.14,3.55,;7.45,6.12,;8.94,6.52,;6.37,7.21,;.92,2.88,;2.46,2.88,;.02,1.64,;.42,.15,;1.9,-.25,;2.3,-1.74,;3.79,-2.13,;1.21,-2.83,;-1.45,2.11,)|
Structure:
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