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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487574
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487574
Synonyms:
US10954193, Example 130
Type:
Small organic molecule
Emp. Form.:
C40H41ClN4O4S
Mol. Mass.:
709.296
SMILES:
Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(Cc3ccc(cc3)C(=O)NS(=O)(=O)c3ccccc3)c12 |(-3.82,-2.33,;-5.16,-3.1,;-5.63,-4.57,;-7.17,-4.57,;-7.94,-5.9,;-7.65,-3.1,;-8.98,-2.33,;-6.4,-2.2,;-6.4,-.66,;-7.74,.11,;-7.74,1.65,;-6.4,2.42,;-5.07,1.65,;-3.61,2.13,;-3.21,3.62,;-1.72,4.01,;-1.32,5.5,;.17,5.9,;1.25,4.81,;.86,3.32,;1.95,2.24,;1.55,.75,;3.43,2.63,;4.52,1.54,;3.83,4.12,;5.32,4.52,;2.74,5.21,;-2.7,.88,;-1.16,.88,;-3.61,-.36,;-3.21,-1.85,;-1.72,-2.25,;-1.32,-3.74,;.17,-4.14,;1.25,-3.05,;.86,-1.56,;-.63,-1.16,;2.74,-3.44,;3.14,-4.93,;3.83,-2.36,;5.32,-2.75,;4.92,-4.24,;6.41,-3.84,;6.41,-1.67,;7.9,-2.06,;8.98,-.98,;8.59,.51,;7.1,.91,;6.01,-.18,;-5.07,.11,)|
Structure:
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