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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM488142
Substrate
n/a
Meas. Tech.
TBD
Ki
54.0±n/a nM
Citation
 Martin, SF; Sahn, JJ; Linkens, KT Sigma receptor binders US Patent  US10954217 Publication Date 3/23/2021 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM488142
Synonyms:
US10954217, Example KTL-01-264
Type:
Small organic molecule
Emp. Form.:
C22H25Cl2N3O2S
Mol. Mass.:
466.424
SMILES:
Clc1cc(Cl)cc(c1)S(=O)(=O)N1CCc2ccc(cc2C1)N1CCN(CC=C)CC1
Structure:
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