| Assay Method Information | |
| | Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay Provider: David Frank, Dana Farber Cancer Institute Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: 1 X01 MH079826-01 Grant Proposal PI: David Frank, Dana Farber Cancer Institute External Assay ID: STAT3_INH_LUMI_1536_IC50 MDCSRUN SAR_ROUND_0 Name: Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors. Description: Members of the signal transducer and activator of transcription (STAT) family of transcription factors mediate inflammation, cell survival, differentiation, and proliferation (1, 2). In response to stimuli such as growth factors and cytokines (1-3), cytosolic STATs are activated by phosphorylation by the Janus-activated kinases (Jaks), inducing STAT dimerization, nuc |
| Affinity data for this assay | |
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