Compile Data Set for Download or QSAR
Report error Found 473 of affinity data for UniProtKB/TrEMBL: P00381
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataKi:  0.00400nMAssay Description:Inhibition constant of compound against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50225252(CHEMBL296525)
Affinity DataKi: <0.0100nMAssay Description:Inhibition constant of compound against Lactobacillus casei Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50027975(5-[2-Bromo-5-(2,4-diamino-pyrimidin-5-ylmethyl)-3-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition constant of compound against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50027973(6-[2-Bromo-5-(2,4-diamino-pyrimidin-5-ylmethyl)-3-...)
Affinity DataKi:  0.400nMAssay Description:Inhibition constant of compound against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50027972(7-[2-Bromo-5-(2,4-diamino-pyrimidin-5-ylmethyl)-3-...)
Affinity DataKi:  0.600nMAssay Description:Inhibition constant of compound against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50027971(4-[2-Bromo-5-(2,4-diamino-pyrimidin-5-ylmethyl)-3-...)
Affinity DataKi:  0.900nMAssay Description:Inhibition constant of compound against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 1.30nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in Bovine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity against dihydrofolate reductase in mammalians. (high potency)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50027977(2-{3-[2-Bromo-5-(2,4-diamino-pyrimidin-5-ylmethyl)...)
Affinity DataKi:  1.70nMAssay Description:Inhibition constant of compound against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291776(3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl...)
Affinity DataKi:  1.80nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50051910((R)-4-Amino-5-(4-{[(2,4-diamino-pyrido[2,3-d]pyrim...)
Affinity DataIC50: 2.20nMAssay Description:Inhibitory activity against recombinant sf dihydrofolate reductase(in 50 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 2.20nMAssay Description:Inhibitory activity against recombinant sf dihydrofolate reductase(in 50 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50041672(2-{4-[3-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyri...)
Affinity DataIC50: 2.5nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in Bovine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291777(3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl...)
Affinity DataKi:  2.5nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50090067(6,6-Dimethyl-1-phenyl-1,6-dihydro-[1,3,5]triazine-...)
Affinity DataKi:  2.60nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291799(1-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MTX-resistant Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Lactobacillus casei ATCC 7469 dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291796(1-(3-Methoxy-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3...)
Affinity DataKi:  3.10nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50405059(CHEMBL7070)
Affinity DataKi:  3.10nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291775(3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl...)
Affinity DataKi:  3.20nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291770(3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl...)
Affinity DataKi:  3.20nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50223502(CHEMBL30603)
Affinity DataKi:  3.20nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291798(1-(3-tert-Butyl-phenyl)-6,6-dimethyl-1,6-dihydro-[...)
Affinity DataKi:  3.20nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50405083(CHEMBL267499)
Affinity DataKi:  3.30nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291793(6,6-Dimethyl-1-(3-trifluoromethyl-phenyl)-1,6-dihy...)
Affinity DataKi:  3.30nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50090054(1-(3-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-...)
Affinity DataKi:  3.5nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 3.52nMAssay Description:Compound was evaluated for inhibitory effect on the dihydrofolate reductase (DHFR) of Lactobacillus casei.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291774(6,6-Dimethyl-1-(3-nitro-phenyl)-1,6-dihydro-[1,3,5...)
Affinity DataKi:  3.60nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50405089(CHEMBL268414)
Affinity DataKi:  3.70nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291779(3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl...)
Affinity DataKi:  3.70nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50405066(CHEMBL268088)
Affinity DataKi:  3.70nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50405092(CHEMBL266025)
Affinity DataKi:  3.70nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50016460(Edatrexate | GNF-Pf-63 | (S)-2-{4-[1-(2,4-Diamino-...)
Affinity DataIC50: 3.80nMAssay Description:Compound was tested for the inhibition of dihydrofolate reductase in Bovine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50028369(2-[4-(2,4-Diamino-pteridin-6-ylmethoxy)-benzoylami...)
Affinity DataIC50: 4nMAssay Description:Concentration required to inhibit Lactobacillus casei derived Dihydrofolate reductase activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50028368(2-[4-(2,4-Diamino-pteridin-6-ylmethylsulfanyl)-ben...)
Affinity DataIC50: 4nMAssay Description:Concentration required to inhibit Lactobacillus casei derived Dihydrofolate reductase activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010932(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoyl...)
Affinity DataIC50: 4nMAssay Description:Concentration required to inhibit Lactobacillus casei derived Dihydrofolate reductase activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50027976({3-[2-Bromo-5-(2,4-diamino-pyrimidin-5-ylmethyl)-3...)
Affinity DataKi:  4.10nMAssay Description:Inhibition constant of compound against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291797(6,6-Dimethyl-1-{3-[2-(3-trifluoromethyl-phenoxy)-e...)
Affinity DataKi:  4.10nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50405087(CHEMBL7435)
Affinity DataKi:  4.20nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291780(1-(3-Benzyloxy-phenyl)-6,6-dimethyl-1,6-dihydro-[1...)
Affinity DataKi:  4.20nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50405099(CHEMBL33750)
Affinity DataKi:  4.40nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50405076(CHEMBL269704)
Affinity DataKi:  4.40nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291801(6,6-Dimethyl-1-(3-tetradecyloxy-phenyl)-1,6-dihydr...)
Affinity DataKi:  4.5nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291800(6,6-Dimethyl-1-(3-undecyloxy-phenyl)-1,6-dihydro-[...)
Affinity DataKi:  4.5nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50405069(CHEMBL287235)
Affinity DataKi:  4.60nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291784(6,6-Dimethyl-1-(3-nonyloxy-phenyl)-1,6-dihydro-[1,...)
Affinity DataKi:  4.70nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291781(5-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)
Affinity DataKi:  4.70nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50405085(CHEMBL6771)
Affinity DataKi:  4.80nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50291805(6,6-Dimethyl-1-{3-[4-(3-trifluoromethyl-phenoxy)-b...)
Affinity DataKi:  4.80nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
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