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TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50271035((S)-4-(1-(1-(3-aza-bicyclo[3.2.2]nonan-3-yl)-3-met...)
Affinity DataKd:  0.200nMAssay Description:Inhibition of bovine carbonic anhydrase2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50514428(CHEMBL4450233)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423786(CHEMBL181397)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423786(CHEMBL181397)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101939(4-Chloro-3-nitro-benzenesulfonamide | CHEMBL51663)
Affinity DataKi:  2nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50044311(Trifluoro-methanesulfonamide | TRIFLUOROMETHANE SU...)
Affinity DataIC50: 2nMAssay Description:Inhibition of bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCarbonic anhydrase 2/3/4/6(Bovine)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50070606(CHEMBL3408993)
Affinity DataKi:  2nMAssay Description:Inhibition of bovine carbonic anhydrase 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50101939(4-Chloro-3-nitro-benzenesulfonamide | CHEMBL51663)
Affinity DataKi:  2nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423785(3,4-Dichloro-Benzenesulfonamide | 3,4-Dichlorobenz...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423785(3,4-Dichloro-Benzenesulfonamide | 3,4-Dichlorobenz...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50175052((2E)-(4-benzoyloxy)but-2-enyl-4-(aminosulfonyl)ben...)
Affinity DataKi:  4.70nMAssay Description:Displacement of DNSA from CAII in bovine erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50175053((2E)-but-2-en-1,4-diyl-bis[(aminosulfonyl)benzoate...)
Affinity DataKi:  4.90nMAssay Description:Displacement of DNSA from CAII in bovine erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50175054((2E)-4-hydroxybut-2-enyl-4-(aminosulfonyl)benzoate...)
Affinity DataKi:  5.30nMAssay Description:Displacement of DNSA from CAII in bovine erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50025094(4-Nitro-benzenesulfonamide | 4-nitrobenzenesulfona...)
Affinity DataKi:  5.60nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50025094(4-Nitro-benzenesulfonamide | 4-nitrobenzenesulfona...)
Affinity DataKi:  5.60nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423784(4-Cyano-Benzenesulfonamide | 4-Cyanobenzenesulfona...)
Affinity DataKi:  7.10nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423784(4-Cyano-Benzenesulfonamide | 4-Cyanobenzenesulfona...)
Affinity DataKi:  7.10nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50175055(1-pentenyl-4-(aminosulfonyl)benzoate | CHEMBL20007...)
Affinity DataKi:  7.70nMAssay Description:Displacement of DNSA from CAII in bovine erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50155501(3-Nitro-benzenesulfonamide | CHEMBL367035)
Affinity DataKi:  8.5nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50155501(3-Nitro-benzenesulfonamide | CHEMBL367035)
Affinity DataKi:  8.5nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50175049(allyl 4-(aminosulfonyl)benzoate | CHEMBL381455)
Affinity DataKi:  8.60nMAssay Description:Displacement of DNSA from CAII in bovine erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50175051((2Z)-4-hydroxybut-2-enyl-4-(aminosulfonyl)benzoate...)
Affinity DataKi:  9.10nMAssay Description:Displacement of DNSA from CAII in bovine erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50175050((2Z)-but-2-en-1,4-diyl-bis[(aminosulfonyl)benzoate...)
Affinity DataKi:  9.30nMAssay Description:Displacement of DNSA from CAII in bovine erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50004262(CHEMBL1438301)
Affinity DataIC50: 11nMAssay Description:Inhibition of bovine erythrocyte carbonic anhydrase 2 using p-nitrophenyl acetate as substrate preincubated for 10 mins before substrate addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM81918(p-Halide-sulfanilamide derivative, 2a)
Affinity DataKi:  14nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50025093(p-Halide-sulfanilamide derivative, 2 | P-Chloroben...)
Affinity DataKi:  14nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM81918(p-Halide-sulfanilamide derivative, 2a)
Affinity DataKi:  14nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50025093(p-Halide-sulfanilamide derivative, 2 | P-Chloroben...)
Affinity DataKi:  14nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423782(3-Chloro-Benzenesulfonamide | 3-Chlorobenzenesulfo...)
Affinity DataKi:  16nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423782(3-Chloro-Benzenesulfonamide | 3-Chlorobenzenesulfo...)
Affinity DataKi:  16nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423783(4-Acetyl-Benzenesulfonamide | 4-Acetylbenzenesulfo...)
Affinity DataKi:  17nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423783(4-Acetyl-Benzenesulfonamide | 4-Acetylbenzenesulfo...)
Affinity DataKi:  17nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50068231(CHEMBL3403326)
Affinity DataIC50: 35nMAssay Description:Inhibition of bovine carbonic anhydrase 2 assessed as hydrolysis of p-nitrophenyl acetate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50236140(4-ethynyl benzene sulfonamide | 4-ethynylbenzenesu...)
Affinity DataKd:  37nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50236140(4-ethynyl benzene sulfonamide | 4-ethynylbenzenesu...)
Affinity DataKd:  37nMAssay Description:Inhibition of bovine carbonic anhydrase2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210908(3-morpholinbenzimidazo[1,2-c][1,2,3]thiadiazole-7-...)
Affinity DataKd:  38nMAssay Description:Binding affinity to bovine CA2 by typical isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50004258(CHEMBL3237498)
Affinity DataIC50: 52nMAssay Description:Inhibition of bovine erythrocyte carbonic anhydrase 2 using p-nitrophenyl acetate as substrate preincubated for 10 mins before substrate addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50068223(CHEMBL3403323)
Affinity DataIC50: 57nMAssay Description:Inhibition of bovine carbonic anhydrase 2 assessed as hydrolysis of p-nitrophenyl acetate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  58nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  58nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50175007(phenyldifluoromethanesulfonamide | CHEMBL371870)
Affinity DataIC50: 58nMAssay Description:Inhibition of bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM36007(3-chloro-5-fluoro-2-methylbenzene-1-sulfonamide | ...)
Affinity DataKd:  96.8nM Kon:  7.88E+5M-1s-1 Koff:  0.0763s-1pH: 7.4 T: 2°CAssay Description:SPR biosensor assay Biacore T100More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2000
Entry Details

TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50068229(CHEMBL3403327)
Affinity DataIC50: 100nMAssay Description:Inhibition of bovine carbonic anhydrase 2 assessed as hydrolysis of p-nitrophenyl acetate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM16661(1-N-(4-fluorobenzene)benzene-1,4-disulfonamide | a...)
Affinity DataIC50: 100nMAssay Description:Inhibition of bovine carbonic anhydrase 2 assessed as hydrolysis of p-nitrophenyl acetate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423780(4-Methoxy-Benzenesulfonamide | 4-Methoxybenzenesul...)
Affinity DataKi:  102nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423780(4-Methoxy-Benzenesulfonamide | 4-Methoxybenzenesul...)
Affinity DataKi:  102nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423781(3-Methylbenzenesulfonamide | Toluene-3-Sulfonamide...)
Affinity DataKi:  132nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50423781(3-Methylbenzenesulfonamide | Toluene-3-Sulfonamide...)
Affinity DataKi:  132nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50068225(CHEMBL3403324)
Affinity DataIC50: 134nMAssay Description:Inhibition of bovine carbonic anhydrase 2 assessed as hydrolysis of p-nitrophenyl acetate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataKi:  137nMAssay Description:Inhibition of bovine erythrocyte carbonic anhydrase 2 using 4-nitrophenyl acetate substrate by photometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
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