Compile Data Set for Download or QSAR
Report error Found 775 of affinity data for UniProtKB/TrEMBL: P02766
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249550(US9434727, 148 | US10072016, Compound 148 | US9777...)
Affinity DataIC50: 0.169nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50225226(4-(2,4-dichlorophenoxy)-3-methoxybenzoic acid | CH...)
Affinity DataKd:  0.200nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50225216(2-(2,4-dichlorophenoxy)-5-(hydroxymethyl)phenol | ...)
Affinity DataKd:  0.300nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249474(US9434727, 73 | US9434727, 77 | US10072016, Compou...)
Affinity DataIC50: 1.62nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | Vyndaqel | US1...)
Affinity DataEC50:  2.70nMAssay Description:Inhibition of wild type TTR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | Vyndaqel | US1...)
Affinity DataEC50:  2.70nMAssay Description:Inhibition of TTR V30M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | Vyndaqel | US1...)
Affinity DataEC50:  2.70nMAssay Description:Inhibition of TTR V122I mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | Vyndaqel | US1...)
Affinity DataKd:  3nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as Kd1 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50197882(CHEMBL3959466)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for first binding sit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2018
Entry Details Article
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50197881(CHEMBL3890392)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for first binding sit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2018
Entry Details Article
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | Vyndaqel | US1...)
Affinity DataKd:  4.40nMAssay Description:Binding affinity to transthyretin (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50197885(CHEMBL3940890 | US20240150297, Compound AG10)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to transthyretin (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50197885(CHEMBL3940890 | US20240150297, Compound AG10)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to human plasma wild type TTR assessed as dissociation constants for second binding site of TTR by isothermal titration calorimetric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2018
Entry Details Article
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249485(US9434727, 83 | US10072016, Compound 83 | US977701...)
Affinity DataIC50: 4.85nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50225217(5-(chloromethyl)-2-(2,4-dichlorophenoxy)phenol | C...)
Affinity DataKd:  5.70nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50609726(CHEMBL5276223)
Affinity DataKd:  6nMAssay Description:Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249481(US9434727, 79 | US10072016, Compound 79 | US977701...)
Affinity DataIC50: 6.10nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50588575(CHEMBL5203058)
Affinity DataKd:  6.20nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50197885(CHEMBL3940890 | US20240150297, Compound AG10)
Affinity DataKd:  7.30nMAssay Description:Binding affinity to human TTR incubated for 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249550(US9434727, 148 | US10072016, Compound 148 | US9777...)
Affinity DataIC50: 7.41nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | Vyndaqel | US1...)
Affinity DataKd:  9.30nMAssay Description:Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for first binding sit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2018
Entry Details Article
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | Vyndaqel | US1...)
Affinity DataKd:  9.90nMAssay Description:Binding affinity to first binding site of wild type TTR (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249534(US9434727, 132 | US10072016, Compound 132 | US9777...)
Affinity DataIC50: 10.5nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249474(US9434727, 73 | US9434727, 77 | US10072016, Compou...)
Affinity DataIC50: 10.6nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249564(US9434727, 162 | US10072016, Compound 162 | US9777...)
Affinity DataIC50: 10.7nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249533(US9434727, 131 | US10072016, Compound 131 | US9777...)
Affinity DataIC50: 10.9nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249538(US9434727, 136 | US10072016, Compound 136 | US9777...)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249466(US9434727, 65 | US10072016, Compound 65 | US977701...)
Affinity DataIC50: 12.7nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249466(US9434727, 65 | US10072016, Compound 65 | US977701...)
Affinity DataIC50: 12.7nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249466(US9434727, 65 | US10072016, Compound 65 | US977701...)
Affinity DataIC50: 12.7nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249466(US9434727, 65 | US10072016, Compound 65 | US977701...)
Affinity DataIC50: 12.8nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50609724(CHEMBL5268339)
Affinity DataKd:  13nMAssay Description:Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249482(US9434727, 80 | US9434727, 81 | US10072016, Compou...)
Affinity DataIC50: 13.9nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50225224(4-(2,4-dichlorophenoxy)-3-hydroxybenzaldehyde | CH...)
Affinity DataKd:  13.9nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM576397(7-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole...)
Affinity DataEC50:  14nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022112919

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50620814(CHEMBL5408344)
Affinity DataKd:  14nMAssay Description:Binding affinity to TTR V122I mutant (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249503(US9434727, 101 | US10072016, Compound 101 | US9777...)
Affinity DataIC50: 14.1nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249520(US9434727, 118 | US10072016, Compound 118 | US9777...)
Affinity DataIC50: 14.2nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249486(US9434727, 84 | US10072016, Compound 84 | US977701...)
Affinity DataIC50: 14.7nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249532(US9434727, 130 | US10072016, Compound 130 | US9777...)
Affinity DataIC50: 14.9nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249482(US9434727, 80 | US9434727, 81 | US10072016, Compou...)
Affinity DataIC50: 15nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249482(US9434727, 80 | US9434727, 81 | US10072016, Compou...)
Affinity DataIC50: 15nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249512(US9434727, 110 | US10072016, Compound 110 | US9777...)
Affinity DataIC50: 15.4nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249480(US9434727, 78 | US10072016, Compound 78 | US977701...)
Affinity DataIC50: 15.8nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249464(US9434727, 63 | US10072016, Compound 63 | US977701...)
Affinity DataIC50: 16nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50620814(CHEMBL5408344)
Affinity DataKd:  16nMAssay Description:Binding affinity to wild-type TTR (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM50609723(CHEMBL5283388)
Affinity DataKd:  16nMAssay Description:Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249489(US9434727, 87 | US10072016, Compound 87 | US977701...)
Affinity DataIC50: 16.4nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249529(US9434727, 127 | US10072016, Compound 127 | US9777...)
Affinity DataIC50: 17nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM576397(7-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole...)
Affinity DataKd:  17nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022112919

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