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TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50405732(CHEMBL290277)
Affinity DataKi:  0.0410nMAssay Description:Compound was tested for inhibition of human (WI-L2) thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50405733(CHEMBL406575)
Affinity DataKi:  0.0420nMAssay Description:Compound was tested for inhibition of human (WI-L2) thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50405731(CHEMBL295708)
Affinity DataKi:  0.0720nMAssay Description:Compound was tested for inhibition of human (WI-L2) thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50277355(CHEMBL4177183)
Affinity DataIC50: 0.0780nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50040861(S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZ...)
Affinity DataKi:  0.0900nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase (purified recombinant human gene) from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50040857((S)-2-{2-Fluoro-4-[(3-methyl-1-oxo-1,2-dihydro-ben...)
Affinity DataKi:  0.0900nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase (purified recombinant human gene) from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50040861(S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZ...)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of TS by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50046660(2-[4-(2-Amino-6-methyl-4-oxo-3,4-dihydro-quinazoli...)
Affinity DataKi:  0.124nMAssay Description:Compound was tested for TS activity against human Thymidylate synthase by tight binding kineticsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50277352(CHEMBL4162649)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50405730(CHEMBL295681)
Affinity DataKi:  0.224nMAssay Description:Compound was tested for inhibition of human (WI-L2) thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50040865(TCMDC-137629 | (S)-2-{4-[(3-Methyl-1-oxo-1,2-dihyd...)
Affinity DataKi:  0.440nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase (purified recombinant human gene) from Escherichia coli.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50040860((S)-2-({5-[(3-Methyl-1-oxo-1,2-dihydro-benzo[f]qui...)
Affinity DataKi:  1.10nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase (purified recombinant human gene) from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50040863((S)-2-{4-[(3-Amino-1-oxo-1,2-dihydro-benzo[f]quina...)
Affinity DataKi:  1.20nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase (purified recombinant human gene) from Escherichia coli.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50326712(2(R)-[4(S)-carboxy-4-[4-[N-(2-hydroxymethyl-4-oxo-...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of thymine synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of thymine synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50027656(CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of thymidylate synthase (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50046665(2-[4-(2,6-Dimethyl-4-oxo-3,4-dihydro-quinazolin-5-...)
Affinity DataKi:  1.31nMAssay Description:Compound was tested for TS activity against human Thymidylate synthase by tight binding kineticsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50161778(Dansyltyrosine deriviative 33B | CHEMBL179448 | (S...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory constant against human thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50005210((2-Imino-1-methyl-1,2-dihydro-benzo[cd]indol-6-yl)...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for the inhibitory constant of human thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50005186((1,5-Dimethyl-2-methylimino-1,2-dihydro-benzo[cd]i...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for the inhibitory constant of human thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50040859((S)-2-{5-[Methyl-(3-methyl-1-oxo-1,2-dihydro-benzo...)
Affinity DataKi:  2.5nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase (purified recombinant human gene) from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50042378(2-[4-(3-Amino-1-oxo-1,2,5,6-tetrahydro-benzo[f]qui...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an Escherichia coli harboring thy A gene cloned from SV40 transformed human fibroblas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615589(CHEMBL264198)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615590(CHEMBL5289121)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615587(CHEMBL109881)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615588(CHEMBL320036)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615593(CHEMBL5287291)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615594(CHEMBL5288172)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615591(CHEMBL5289689)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615592(CHEMBL5283610)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615597(CHEMBL5282201)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615598(CHEMBL5266971)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615595(CHEMBL5268759)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615596(CHEMBL5286548)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615599(CHEMBL5271165)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615600(CHEMBL5273148)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615585(CHEMBL111859)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615586(CHEMBL113019)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615583(CHEMBL321678)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50615584(CHEMBL5267424)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50040862((S)-2-{6-[(3-Methyl-1-oxo-1,2-dihydro-benzo[f]quin...)
Affinity DataKi:  4nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase (purified recombinant human gene) from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50035018(5,N*6*-Dimethyl-N*6*-(2-methyl-pyridin-4-ylmethyl)...)
Affinity DataKi:  4nMAssay Description:Inhibitory effect against recombinant human thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50161777((S)-3-[4-(5-Dimethylamino-naphthalene-1-sulfonylox...)
Affinity DataKi:  4.10nMAssay Description:Inhibitory constant against human thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50008294(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity against thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50022231(4-{4-[4-(2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylm...)
Affinity DataIC50: 4.70nMAssay Description:Inhibitory activity against thymidylate synthase of Streptococcus faeciumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50040858(2-[4-(3-Methyl-1-oxo-1,2-dihydro-benzo[f]quinazoli...)
Affinity DataKi:  5.5nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase (purified recombinant human gene) from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50040858(2-[4-(3-Methyl-1-oxo-1,2-dihydro-benzo[f]quinazoli...)
Affinity DataKi:  5.5nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an Escherichia coli harboring thy A gene cloned from SV40 transformed human fibroblas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50022234(4-[4-(4-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmeth...)
Affinity DataIC50: 5.5nMAssay Description:Inhibitory activity against thymidylate synthase of Streptococcus faeciumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50005329(CHEMBL168524 | 5-[4-(Morpholine-4-sulfonyl)-benzyl...)
Affinity DataKi:  6nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Pedagogical University

Curated by ChEMBL
LigandPNGBDBM50022235(CID44294491 | 4-(4-{4-[4-(2-{4-[(2-Amino-4-hydroxy...)
Affinity DataIC50: 6.30nMAssay Description:Inhibitory activity against thymidylate synthase of Streptococcus faeciumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
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