Compile Data Set for Download or QSAR
Report error Found 229 of affinity data for UniProtKB/TrEMBL: P05981
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580332(CHEMBL5081575)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50518599(CHEMBL4454016)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged hepsin catalytic domain preincubated for 30 mins followed by Boc-QAR-AMC substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50518598(CHEMBL4540950)
Affinity DataKi:  0.160nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged hepsin catalytic domain preincubated for 30 mins followed by Boc-QAR-AMC substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639175(CHEMBL5558547)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of C-terminal 10-His tagged human recombinant hepsin (Arg45 to Leu417 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details

TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639183(CHEMBL5568169)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of C-terminal 10-His tagged human recombinant hepsin (Arg45 to Leu417 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details

TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032999(CHEMBL3356597)
Affinity DataKi:  0.210nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032934(CHEMBL3356591)
Affinity DataKi:  0.210nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032936(CHEMBL3356589)
Affinity DataKi:  0.220nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50512105(CHEMBL4587327)
Affinity DataKi:  0.270nMAssay Description:Inhibition of recombinant human hepsin preincubated for 30 mins followed by Boc-QLR-AMC substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032931(CHEMBL3356594)
Affinity DataKi:  0.280nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639177(CHEMBL5564865)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of C-terminal 10-His tagged human recombinant hepsin (Arg45 to Leu417 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details

TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032930(CHEMBL3356595)
Affinity DataKi:  0.340nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580346(CHEMBL5074750)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032698(CHEMBL3354676 | N-0130)
Affinity DataKi:  0.380nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032935(CHEMBL3356590)
Affinity DataKi:  0.410nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032947(CHEMBL3356606)
Affinity DataKi:  0.470nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM525256(N-0438 | (H)Arg-Glu-Phe-Arg-kbt)
Affinity DataKi:  0.520nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataKi:  0.530nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataKi:  0.530nMAssay Description:Inhibition of hepsin (unknown origin) using Boc-QAR-AMC as substrate after 30 mins prior to substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639180(CHEMBL5559738)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of C-terminal 10-His tagged human recombinant hepsin (Arg45 to Leu417 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details

TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032941(CHEMBL3356600)
Affinity DataKi:  0.550nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032991(CHEMBL3356596)
Affinity DataKi:  0.570nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM525152(US10988505, Example 2 | N-0385 | Ms-QFR-kbt)
Affinity DataKi:  0.570nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032933(CHEMBL3356592)
Affinity DataKi:  0.580nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032940(CHEMBL3356599)
Affinity DataKi:  0.600nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM525153(US10988505, Example 3 | N-0386 | Ac-QFR-kbt)
Affinity DataKi:  0.600nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032945(CHEMBL3356604)
Affinity DataKi:  0.610nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50512103(CHEMBL4464524)
Affinity DataKi:  0.670nMAssay Description:Inhibition of recombinant human hepsin preincubated for 30 mins followed by Boc-QLR-AMC substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032944(CHEMBL3356603)
Affinity DataKi:  0.680nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639179(CHEMBL5560415)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of C-terminal 10-His tagged human recombinant hepsin (Arg45 to Leu417 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details

TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50135269(CHEMBL3745775)
Affinity DataKi:  0.830nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639176(CHEMBL5560759)
Affinity DataIC50: 0.910nMAssay Description:Inhibition of C-terminal 10-His tagged human recombinant hepsin (Arg45 to Leu417 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details

TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639172(CHEMBL5561725)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of C-terminal 10-His tagged human recombinant hepsin (Arg45 to Leu417 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details

TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50135268(CHEMBL3747482)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50420334(CHEMBL2086421)
Affinity DataKi:  1.10nMAssay Description:Tight binding inhibition of human hepsin expressed in Drosophila melanogaster S2 cells using Boc-QAR-AMC as substrate incubated for 15 mins prior to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032939(CHEMBL3356598)
Affinity DataKi:  1.20nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032946(CHEMBL3356605)
Affinity DataKi:  1.20nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032943(CHEMBL3356602)
Affinity DataKi:  1.40nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032936(CHEMBL3356589)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50518596(CHEMBL4463174)
Affinity DataKi:  1.70nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged hepsin catalytic domain preincubated for 30 mins followed by Boc-QAR-AMC substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580331(CHEMBL5083517)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50032932(CHEMBL3356593)
Affinity DataKi:  2.10nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639178(CHEMBL5557087)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of C-terminal 10-His tagged human recombinant hepsin (Arg45 to Leu417 residues) using Boc-QAR-AMC as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details

TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50135270(CHEMBL3747468)
Affinity DataKi:  2.90nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50135275(CHEMBL3746517)
Affinity DataKi:  2.90nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50135274(CHEMBL404190)
Affinity DataKi:  3.40nMAssay Description:Inhibition of human recombinant hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 15 to 120 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataKi:  4.20nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580335(CHEMBL5092327)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580342(CHEMBL5088958)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
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